Description

(5-Aminopentanoyl)Melittin is a chemically modified analog of the principal bioactive peptide, melittin, found in bee venom. This modification, introducing a 5-aminopentanoyl group, is designed to alter its biological activity and physicochemical properties for advanced research and development applications. It is a critical tool for researchers in biochemistry, pharmacology, and biotechnology exploring novel peptide therapeutics, antimicrobial agents, and cell membrane interaction studies. The compound is supplied to meet the stringent requirements of laboratory and pre-clinical investigations.

Application

• Biomedical Research: Fundamental studies on peptide-membrane interactions, cytotoxicity mechanisms, and the structure-activity relationships (SAR) of melittin derivatives.
• Drug Discovery: Serving as a lead compound or a molecular probe in the development of new antimicrobial, anticancer, or anti-inflammatory agents.
• Biophysical Studies: Utilization in model membrane systems (e.g., liposomes) to investigate pore-formation, membrane permeability, and lytic activity.
• Bioconjugation & Carrier Systems: The primary amine group on the pentanoyl chain provides a handle for further chemical conjugation to drug carriers, fluorescent labels, or other bioactive molecules.
• Enzyme & Receptor Studies: Investigation of its potential as an inhibitor or modulator for specific enzymatic or cellular receptor targets.

Basic Information

Product Name	(5-Aminopentanoyl)Melittin
CAS No.	142675-05-6
Molecular Formula	C₁₅₂H₂₆₆N₄₄O₄₅
Molecular Weight	~3486.9 g/mol
Synonyms	5-Aminopentanoyl-melittin; Nε-(5-Aminopentanoyl)-Melittin; Melittin, 5-aminopentanoyl derivative; AP-Melittin; Lys7-(5-aminopentanoyl)melittin; Modified Melittin Peptide; Cationic Lytic Peptide Derivative
EINECS	Contact for details

Quality Control

Every batch of (5-Aminopentanoyl)Melittin is produced and analyzed under controlled conditions to ensure high purity and batch-to-batch consistency for research applications. Our quality assurance includes rigorous analytical testing by HPLC and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.