Description

S-(2-Bromo-2-Chloro-1,1-Difluoroethyl)Cysteine is a specialized organofluorine and organosulfur compound, serving as a critical synthetic intermediate in advanced pharmaceutical and agrochemical research. Its unique structure, featuring a reactive cysteine moiety bonded to a halogenated difluoroethyl group, makes it a valuable building block for constructing complex molecules with targeted biological activity. This compound is essential for researchers and manufacturers in medicinal chemistry, particularly for developing novel enzyme inhibitors and investigating metabolic pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting enzyme active sites via covalent modification.
• Medicinal Chemistry Research: Used as a building block for creating chemical libraries to study structure-activity relationships (SAR) in drug discovery.
• Bioconjugation & Probe Development: Utilized in the development of activity-based protein profiling (ABPP) probes and affinity labels due to its reactive cysteine-targeting electrophile.
• Agrochemical Synthesis: Intermediate in the research and development of new pesticides and herbicides with unique modes of action.
• Biochemical Tool Compound: Serves as a reagent in biochemical assays to study cysteine protease inhibition and redox biology.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	S-(2-Bromo-2-Chloro-1,1-Difluoroethyl)Cysteine
CAS No.	142628-08-8
Molecular Formula	C5H7BrClF2NO2S
Molecular Weight	298.53 g/mol
Synonyms	L-Cysteine, S-(2-bromo-2-chloro-1,1-difluoroethyl)-; S-(2-Bromo-2-chloro-1,1-difluoroethyl)-L-cysteine; (2R)-2-Amino-3-[[(2-bromo-2-chloro-1,1-difluoroethyl)sulfanyl]propanoic acid; BCDF-Cysteine; 2-Bromo-2-chloro-1,1-difluoroethyl cysteine adduct; Halothane-cysteine conjugate
EINECS	Contact for details

Quality Control

Our S-(2-Bromo-2-Chloro-1,1-Difluoroethyl)Cysteine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere to maintain stability and prevent degradation. The compound is moisture-sensitive; ensure containers are sealed and allowed to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.