Description

7-Amino-1-Cyclopropyl-3-Ethyl-1,2,3,4-Tetrahydro-2,4-Dioxopyrido[2,3-D]Pyrimidine-6-Carboxamide is a high-purity pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of novel, potent therapeutic agents, particularly within the antibacterial and anticancer research fields. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences industry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel topoisomerase inhibitors and antibacterial agents.
• Antibacterial Drug Research: Used in the development of next-generation quinolone and fluoroquinolone analogs targeting resistant bacterial strains.
• Oncology Research: Serves as a core scaffold for creating targeted cancer therapies, including kinase inhibitors.
• Chemical Synthesis: Employed in academic and industrial research for constructing complex heterocyclic systems and exploring structure-activity relationships (SAR).
• Process Development: Used for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under cGMP conditions.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	7-Amino-1-Cyclopropyl-3-Ethyl-1,2,3,4-Tetrahydro-2,4-Dioxopyrido[2,3-D]Pyrimidine-6-Carboxamide
CAS No.	142557-61-7
Molecular Formula	C₁₃H₁₅N₅O₃
Molecular Weight	289.29 g/mol
Synonyms	7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide; ABT-492 Intermediate; Dihydrofolate Reductase Inhibitor Intermediate; Quinolone Pyrimidine Intermediate; 6-Carboxamide Derivative; 1-Cyclopropyl-3-ethyl-7-amino-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 7-Amino-1-Cyclopropyl-3-Ethyl-1,2,3,4-Tetrahydro-2,4-Dioxopyrido[2,3-D]Pyrimidine-6-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.