Description

Hemoglobin A2 Parkville is a highly purified, standardized reference material of the human hemoglobin A2 variant, identified by CAS No. 142192-02-7. This product is essential for ensuring the accuracy and reliability of diagnostic assays and research focused on hemoglobinopathies, such as β-thalassemia. It serves as a critical quality control standard for clinical laboratories, diagnostic kit manufacturers, and biomedical research institutions engaged in hematological studies.

Application

• Primary Reference Standard for the calibration and validation of HPLC, capillary electrophoresis, and other analytical systems used in hemoglobin variant analysis.
• Quality Control Material in the manufacturing and lot-release testing of in-vitro diagnostic (IVD) kits for thalassemia and hemoglobin disorder screening.
• Research Reagent for biochemical studies investigating the structure, function, and pathophysiology of hemoglobin A2.
• Method Development & Verification in clinical and research laboratories to establish new protocols or verify existing methods for hemoglobin separation and quantification.
• Proficiency Testing programs to assess and ensure the competency of laboratory personnel and the performance of analytical equipment.
• Educational Tool for training purposes in clinical chemistry and hematology departments within academic and medical institutions.

Basic Information

Product Name	Hemoglobin A2 Parkville
CAS No.	142192-02-7
Molecular Formula	C?H?N?O?S?Fe (Contact for details)
Molecular Weight	~64,500 Da (Tetramer) - Contact for details
Synonyms	Hb A2; Hemoglobin A2; Hemoglobin δ2β2; Delta2-Beta2 Globin Tetramer; Human Hemoglobin A2; Hemoglobin Variant A2; Diagnostic Hemoglobin A2; Reference Hemoglobin A2; HbA2 Standard
EINECS	Contact for details

Quality Control

Our Hemoglobin A2 Parkville is manufactured under strict controls to ensure it meets the high-purity requirements for diagnostic and research applications. Each lot is characterized using advanced analytical techniques including HPLC and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment, supporting compliance with ISO 13485 and relevant IVD regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider aliquoting and freezing at -20°C or below under inert conditions.

Specification

Item	Specification
Appearance	Lyophilized powder or specified solution
Identification (HPLC)	Conforms to reference retention time
Identification (Electrophoresis)	Migrates as a single band corresponding to Hb A2
Purity (HPLC)	≥ 95.0% (Hb A2)
Related Hemoglobins (HPLC)	Total ≤ 5.0% (Hb A, Hb F, etc.)
Solubility	Clear solution in specified buffer
Protein Concentration	As per COA (e.g., mg/mL)
Biological Activity	Oxygen binding capacity confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.