Description

n-Fmoc-S-(4-Methoxybenzyl)-L-Cysteine is a protected derivative of the amino acid L-cysteine, featuring an Fmoc (9-fluorenylmethoxycarbonyl) group on the amine and an S-(4-methoxybenzyl) group on the thiol side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity, protected amino acids for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the controlled elongation of peptide chains.
• Pharmaceutical Research: Used in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Serves as a precursor for introducing thiol-reactive handles or for site-specific labeling of biomolecules after deprotection.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Tool Development: Used to synthesize peptide substrates, inhibitors, or probes for studying enzyme activity and protein-protein interactions.
• Material Science: Can be incorporated into peptide-based polymers or hydrogels where the cysteine thiol functionality is required for cross-linking.

Basic Information

Product Name	n-Fmoc-S-(4-Methoxybenzyl)-L-Cysteine
CAS No.	141892-41-3
Molecular Formula	C27H27NO5S
Molecular Weight	477.57 g/mol
Synonyms	Fmoc-Cys(Mob)-OH; Fmoc-S-(4-Methoxybenzyl)-L-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)methyl]-L-cysteine; L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)methyl]-; Fmoc-Cys(MBzl)-OH; Fmoc-L-Cysteine(S-4-methoxybenzyl); N-Fmoc-S-p-methoxybenzyl-L-cysteine
EINECS	Contact for details

Quality Control

Our n-Fmoc-S-(4-Methoxybenzyl)-L-Cysteine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.