Description

Endomorphin-2 is a potent, highly selective endogenous opioid peptide that acts primarily on the mu-opioid receptor. This compound is of significant interest in advanced neuroscience and pharmaceutical research due to its role in modulating pain perception and its potential implications for developing novel analgesic therapies. It is a critical reagent for researchers and developers in the fields of neuropharmacology, peptide chemistry, and central nervous system drug discovery.

Application

• Neuroscience Research: Used as a selective agonist to study mu-opioid receptor signaling pathways, neuronal excitability, and pain modulation mechanisms in vitro and in vivo.
• Analgesic Drug Development: Serves as a reference standard and a lead compound in the discovery and optimization of novel, non-addictive pain management therapeutics.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays (e.g., cAMP inhibition, calcium flux), and high-throughput screening campaigns to identify new modulators.
• Peptide Chemistry & Conjugation: Acts as a core structure for synthesizing labeled derivatives (e.g., fluorescent, radioactive) for imaging and pharmacokinetic studies.
• Academic & Institutional Research: Essential for universities and research institutes investigating the endogenous opioid system, stress response, and reward pathways.

Basic Information

Product Name	Endomorphin-2
CAS No.	141801-26-5
Molecular Formula	C27H35N5O5
Molecular Weight	509.60 g/mol
Synonyms	Tyr-Pro-Phe-Phe-NH2; H-Tyr-Pro-Phe-Phe-NH2; Endomorphin 2; Endomorphin-2 (human, mouse, rat); Opioid peptide Endomorphin-2; YPFF-NH2; Mu-opioid receptor agonist peptide
EINECS	Contact for details

Quality Control

Our Endomorphin-2 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 98%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.