Description

Cyclopentanecarboxylic Acid, 3-(Acetylamino)-4-Fluoro-, Methyl Ester, (1Alpha,3Alpha,4Beta)- (9Ci) is a high-purity, stereochemically defined fluorinated cyclopentane derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates fluorine and acetamide functional groups on a constrained cyclopentane ring system, enabling precise modulation of biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where stereochemistry and fluorination are key design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Research: Used as a sophisticated building block in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances bioavailability and stability.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to explore the impact of fluorination and specific stereochemistry on drug candidate profiles.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its potential as a transition-state analog.
• Academic & Institutional Research: Provides a valuable tool for synthetic methodology development and exploring new reactions involving fluorinated, stereodefined carbocycles.

Basic Information

Product Name	Cyclopentanecarboxylic Acid, 3-(Acetylamino)-4-Fluoro-, Methyl Ester, (1Alpha,3Alpha,4Beta)- (9Ci)
CAS No.	141765-39-1
Molecular Formula	C9H14FNO3
Molecular Weight	203.21 g/mol
Synonyms	(1α,3α,4β)-3-(Acetylamino)-4-fluorocyclopentanecarboxylic acid methyl ester; Methyl (1α,3α,4β)-3-acetamido-4-fluorocyclopentanecarboxylate; 3-Acetamido-4-fluorocyclopentanecarboxylic acid methyl ester (1α,3α,4β)-; (1R,3R,4S)-3-Acetamido-4-fluorocyclopentanecarboxylic acid methyl ester; Fluorocyclopentane carboxamide derivative; 141765-39-1; Methyl 3-acetamido-4-fluorocyclopentanecarboxylate
EINECS	Contact for details

Quality Control

Every batch of Cyclopentanecarboxylic Acid, 3-(Acetylamino)-4-Fluoro-, Methyl Ester, (1Alpha,3Alpha,4Beta)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, meeting the exacting standards required for research and development. A detailed Certificate of Analysis (COA) including results from chiral HPLC, NMR, and mass spectrometry is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.