Description

D-Tryptophan Benzyl Ester is a protected derivative of the essential amino acid D-tryptophan, where the carboxylic acid group is esterified with benzyl alcohol. This modification enhances its stability and solubility in organic solvents, making it a crucial chiral building block for sophisticated chemical synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptides, peptidomimetics, and other bioactive compounds where the D-configuration of tryptophan is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-tryptophan residue, which can confer metabolic stability and unique conformational properties to peptides.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, receptor-ligand interaction research, and metabolic pathway investigations.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric catalytic reactions to construct complex molecules with high enantiomeric purity.
• Protecting Group Strategy: The benzyl ester group can be selectively removed under mild hydrogenolytic conditions, allowing for sequential synthesis strategies in complex molecule assembly.

Basic Information

Product Name	D-Tryptophan Benzyl Ester
CAS No.	141595-98-4
Molecular Formula	C19H20N2O2
Molecular Weight	308.38 g/mol
Synonyms	D-Tryptophan benzyl ester; (R)-2-Amino-3-(1H-indol-3-yl)propanoic acid benzyl ester; Benzyl D-tryptophanate; (R)-Benzyl 2-amino-3-(1H-indol-3-yl)propanoate; H-D-Trp-OBzl; D-Trp-OBzl; Boc-D-Trp-OBzl (when protected); Fmoc-D-Trp-OBzl (when protected)
EINECS	Contact for details

Quality Control

Our D-Tryptophan Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.