Description

Ethyl 3-Ethoxy-2,2-Difluoro-3-Hydroxypropionate is a specialized fluorinated organic ester building block. This compound is valued for its unique molecular structure, which incorporates both fluorine atoms and a reactive hydroxy group, making it a versatile intermediate for advanced synthesis. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate potency, bioavailability, and metabolic profile.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoro and ethoxy groups contribute to efficacy and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and coatings with tailored properties such as chemical resistance, low surface energy, and durability.
• Organic Synthesis Reagent: A versatile reagent in academic and industrial R&D for introducing the 2,2-difluoro-3-hydroxypropionate moiety into more complex molecular architectures.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) and developing new fluorination methodologies in medicinal and synthetic chemistry.

Basic Information

Product Name	Ethyl 3-Ethoxy-2,2-Difluoro-3-Hydroxypropionate
CAS No.	141546-97-6
Molecular Formula	C7H12F2O4
Molecular Weight	198.17 g/mol
Synonyms	Ethyl 3-Ethoxy-2,2-Difluoro-3-Hydroxypropanoate; 3-Ethoxy-2,2-Difluoro-3-Hydroxypropionic Acid Ethyl Ester; 2,2-Difluoro-3-ethoxy-3-hydroxypropionic Acid Ethyl Ester; Ethyl 2,2-Difluoro-3-Ethoxy-3-Hydroxypropionate; 141546-97-6; EFDP; Difluoro Hydroxy Ester Intermediate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Ethoxy-2,2-Difluoro-3-Hydroxypropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.