Description

2-Fluoro-5-(Trifluoromethyl)Phenol is a high-value fluorinated phenolic intermediate with unique electronic and steric properties imparted by its fluorine and trifluoromethyl substituents. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where its structure enables fine-tuning of molecular interactions and stability. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Polymer Modification: Incorporated into polymer chains to impart specific properties like chemical resistance, low surface energy, or altered dielectric constant.
• Organic Synthesis Reagent: Acts as a versatile coupling partner in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing the phenol moiety into complex molecules.
• Material Science Research: Utilized in the development of organic semiconductors, metal-organic frameworks (MOFs), and other advanced functional materials.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Phenol
CAS No.	141483-15-0
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	2-Fluoro-5-(trifluoromethyl)phenol; 2-Fluoro-alpha,alpha,α-trifluoro-p-cresol; 5-(Trifluoromethyl)-2-fluorophenol; 2-Fluoro-5-trifluoromethylphenol; Phenol, 2-fluoro-5-(trifluoromethyl)-; 2-Fluoro-α,α,α-trifluoro-p-cresol; 2-Fluoro-5-(trifluoromethyl)hydroxybenzene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.