Description

Boc-Val-Nca is a protected amino acid N-carboxyanhydride (NCA) derivative, a critical building block in the solid-phase and solution-phase synthesis of peptides and peptidomimetics. Its primary value lies in enabling the controlled, racemization-free introduction of the valine residue under mild conditions, which is essential for producing high-purity, structurally defined peptides. This compound is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and efficient peptide chain assembly.

Application

• Pharmaceutical Intermediate: Key monomer for the synthesis of therapeutic peptides, including hormone analogs and antimicrobial peptides.
• Bioconjugation: Used to create valine-terminated polymer chains or surfaces for coupling with biomolecules like proteins or antibodies.
• Polymer Chemistry: Serves as a specialized monomer for the ring-opening polymerization (ROP) to produce poly(amino acid)s and functional biomaterials.
• Research & Development: Fundamental reagent in academic and industrial R&D for exploring new peptide-based drugs, drug delivery systems, and biomaterials.
• Combinatorial Chemistry: Employed in automated peptide synthesizers for generating diverse peptide libraries for screening purposes.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of complex, non-standard peptide sequences.

Basic Information

Product Name	Boc-Val-Nca
CAS No.	141468-55-5
Molecular Formula	C11H17NO5
Molecular Weight	243.26 g/mol
Synonyms	Nα-(tert-Butoxycarbonyl)-L-valine N-carboxyanhydride; Boc-L-valine NCA; Boc-Valine N-Carboxyanhydride; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid anhydride; 1-(tert-Butoxycarbonyl)-L-valine anhydride; N-tert-Butoxycarbonyl-L-valine N-carboxyanhydride; Boc-Val-NCA; BOC-Val-NCA
EINECS	Contact for details

Quality Control

Our Boc-Val-Nca CAS NO 141468-55-5 is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR/IR for structural verification. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]D20: -15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DCM; slightly soluble in ethyl acetate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.