Description

(Cys3,6,Tyr8,Pro9)-Substance P CAS NO 141459-28-1 is a synthetic, site-specifically modified analog of the endogenous neuropeptide Substance P. This compound is of significant value in biochemical and pharmacological research due to its targeted modifications, which alter receptor binding affinity and functional activity compared to the native peptide. It is primarily utilized by research institutions and pharmaceutical developers focused on neuroscience, pain signaling pathways, and neurokinin receptor (NK1) studies.

Application

• Neuroscience Research: As a key tool for investigating the role of Substance P and its receptors in pain transmission, neuroinflammation, and central nervous system disorders.
• Receptor Binding Assays: Used in competitive binding studies to characterize the affinity and specificity of neurokinin-1 (NK1) receptor ligands.
• Pharmacological Profiling: Employed in vitro and in vivo to study the effects of modified peptide sequences on biological activity and metabolic stability.
• Biochemical Standard: Serves as a high-purity reference standard for analytical method development and validation in peptide analysis.
• Drug Discovery: A starting point or intermediate for the design and synthesis of novel peptide-based therapeutics targeting neurokinin pathways.

Basic Information

Product Name	(Cys3,6,Tyr8,Pro9)-Substance P
CAS No.	141459-28-1
Molecular Formula	C63H89N15O13S2
Molecular Weight	1320.6 g/mol
Synonyms	[Cys3,6,Tyr8,Pro9]-Substance P; Substance P (3-6,8-9) analog; Arg-Pro-Lys-Cys-Pro-Gln-Cys-Tyr-Pro-Gln-Leu-NH2 (Disulfide bridge: Cys3-Cys6); Modified Substance P analog; Neurokinin-1 receptor ligand analog; SP analog; Tachykinin peptide analog
EINECS	Contact for details

Quality Control

Every batch of (Cys3,6,Tyr8,Pro9)-Substance P is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards for research-grade bioactive peptides. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, amino acid analysis, and mass spectrometry is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.