Description

Bovine Peripheral-Type Benzodiazepine Receptor Isoquinoline-Binding Protein is a highly purified protein isolate derived from bovine tissue, specifically targeting the peripheral-type benzodiazepine receptor (PBR), now more commonly referred to as the translocator protein (TSPO). This specialized biochemical is a critical tool for researchers investigating the role of TSPO in cellular processes such as cholesterol transport, steroidogenesis, apoptosis, and mitochondrial function. It is primarily utilized in neuroscience, pharmacology, and biochemistry research for binding assays, receptor characterization, and the development of diagnostic or therapeutic agents targeting neuroinflammation and neurological disorders.

Application

• Biochemical Research: Used as a standard or reagent in radioligand binding assays and competitive inhibition studies to characterize the TSPO receptor and screen novel compounds.
• Neuroscience Studies: Essential for investigating the role of TSPO in neuroinflammation, glial cell activation, and its implications in conditions like Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
• Drug Discovery & Development: Serves as a key target protein in high-throughput screening (HTS) platforms for identifying and optimizing potential therapeutic ligands for neurological and psychiatric disorders.
• Diagnostic Tool Development: Employed in the research and development of molecular imaging probes (e.g., for PET scans) that target TSPO to visualize neuroinflammation in vivo.
• Cellular & Molecular Biology: Used to study mitochondrial function, apoptosis regulation, and steroid hormone synthesis pathways in various cell models.
• Antibody Production & Validation: Acts as a purified antigen for the generation and validation of specific antibodies against the bovine TSPO isoform for use in Western blotting, immunohistochemistry, and ELISA.

Basic Information

Item	Details
Product Name	Bovine Peripheral-Type Benzodiazepine Receptor Isoquinoline-Binding Protein
CAS No.	141440-82-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bovine TSPO; Bovine Translocator Protein (18 kDa); Bovine Peripheral Benzodiazepine Receptor; PBR Protein (Bovine); Isoquinoline Binding Protein (Bovine); PKBS Protein (Bovine); Cholesterol-Binding Peripheral Protein (Bovine); Benzodiazepine Peripheral Receptor Site Ligand (Bovine)
EINECS	Contact for details

Quality Control

Our Bovine Peripheral-Type Benzodiazepine Receptor Isoquinoline-Binding Protein is produced and handled under stringent conditions to ensure high biological activity and batch-to-batch consistency. Each lot undergoes rigorous quality testing, including assessment of purity, protein concentration, and functional activity in standard binding assays. Certificates of Analysis (COA) detailing specific test results are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles and maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single major band at ~18 kDa
Purity (HPLC)	≥ 90%
Protein Content (BCA)	≥ 85%
Biological Activity (Binding Assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.