Description

(R)-7-(3-Aminohexahydro-1H-Azepin-1-Yl)-8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone carboxylic acid class. This compound is critical for the synthesis of novel, potent antibacterial agents, offering a key chiral building block for research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation antibiotic therapies.

Application

• Key Intermediate for Antibacterial Agents: Serves as a crucial chiral precursor in the synthesis of advanced fluoroquinolone antibiotics.
• Pharmaceutical R&D: Used in medicinal chemistry for the discovery and development of new antibacterial compounds with improved efficacy and safety profiles.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory submissions.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) in quinolone chemistry.

Basic Information

Product Name	(R)-7-(3-Aminohexahydro-1H-Azepin-1-Yl)-8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	141388-76-3
Molecular Formula	C19H22ClFN4O3
Molecular Weight	408.86 g/mol
Synonyms	(R)-Ofloxacin Intermediate; (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; (R)-8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivative; Dexofloxacin Intermediate; Levofloxacin-related intermediate; (R)-enantiomer of OFX intermediate; (3R)-7-(3-Aminoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-7-(3-Aminohexahydro-1H-Azepin-1-Yl)-8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.