Description

Lys-Psi(Ch2Nh)-Trp(Nps)-Ome CAS NO 141365-20-0 is a specialized synthetic peptide derivative, specifically a reduced amide bond (ψ[CH₂NH]) pseudopeptide analog. This compound is of significant value in advanced pharmaceutical research and development, particularly in the study of peptide structure-activity relationships and metabolic stability. It serves as a critical intermediate or reference standard for researchers in medicinal chemistry and biochemistry. Target users include R&D laboratories and pharmaceutical companies focused on developing novel therapeutic agents, enzyme inhibitors, and diagnostic tools.

Application

• Medicinal Chemistry Research: Used as a key intermediate in the synthesis of pseudopeptide analogs for drug discovery programs.
• Enzyme Inhibition Studies: Serves as a substrate or inhibitor analog in biochemical assays to study protease and other enzyme mechanisms.
• Structure-Activity Relationship (SAR) Analysis: Provides a model compound for investigating the impact of amide bond replacement on peptide bioactivity and stability.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in peptide API manufacturing.
• Bioconjugation & Probe Development: The Nps (o-Nitrophenylsulfenyl) protecting group offers potential for selective deprotection and further functionalization in probe synthesis.

Basic Information

Product Name	Lys-Psi(Ch2Nh)-Trp(Nps)-Ome
CAS No.	141365-20-0
Molecular Formula	C32H43N7O7S
Molecular Weight	669.80 g/mol
Synonyms	Lysyl-ψ[CH₂NH]-tryptophyl(Nps) methyl ester; Nε-Boc-Lys-ψ[CH₂NH]-Trp(Nps)-OMe; Boc-Lys-ψ[CH₂NH]-Trp(Nps)-OMe; Reduced amide bond pseudopeptide Lys-Trp analog; Methyl Nε-tert-butoxycarbonyl-L-lysyl-N-[2-[[(2S)-1-methoxy-3-(2-[[(2-nitrophenyl)sulfanyl]amino]-1H-indol-3-yl)-1-oxopropan-2-yl]amino]ethyl]-L-norleucinamide; (S)-Methyl 2-((S)-2-((S)-6-((tert-butoxycarbonyl)amino)-2-((2-((S)-2-((2-((2-nitrophenyl)thio)amino)-1H-indol-3-yl)-1-methoxy-1-oxopropan-2-yl)amino)ethyl)amino)hexanamido)pentanoate
EINECS	Contact for details

Quality Control

Our Lys-Psi(Ch2Nh)-Trp(Nps)-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, supporting compliance with research and cGMP guidelines for non-clinical materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.