Description

Toxin 3, Centruroides Noxius CAS NO 141322-34-1 is a highly purified, biologically active peptide toxin isolated from the venom of the Mexican scorpion Centruroides noxius. This compound is a critical tool in neuroscience and pharmacological research, specifically targeting voltage-gated sodium channels. It is essential for researchers and pharmaceutical developers in the fields of neurobiology, ion channel characterization, and the development of novel therapeutic agents or bio-insecticides.

Application

• Neuroscience Research: A key tool for studying the function, modulation, and block of voltage-gated sodium (NaV) channels in neuronal and muscular tissues.
• Drug Discovery & Pharmacology: Used in high-throughput screening assays to identify and characterize new channel modulators, analgesics, or anticonvulsants.
• Toxicology & Venom Studies: Serves as a reference standard for analyzing scorpion venom composition and studying the mechanisms of envenomation.
• Ion Channel Characterization: Employed in electrophysiology (e.g., patch-clamp) experiments to probe specific NaV channel subtypes and their role in disease states.
• Biochemical Reagent: Used in the development of sensitive immunoassays or as a ligand in receptor-binding studies.
• Academic & Institutional Research: Fundamental reagent for universities and research institutes conducting basic research on excitability and signal transduction.

Basic Information

Product Name	Toxin 3, Centruroides Noxius
CAS No.	141322-34-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cn3 Toxin; Centruroides noxius Toxin III; NaV Channel Toxin Cn3; β-toxin Cn3; Scorpion Toxin Cn3; Insect-Selective Toxin; Neurotoxin III (Centruroides noxius); Sodium Channel Neurotoxin
EINECS	Contact for details

Quality Control

Every batch of Toxin 3, Centruroides Noxius is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Our quality assurance includes rigorous testing via HPLC, mass spectrometry, and bioactivity assays. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical results is provided with each shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into working volumes to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity	Confirmed by assay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.