Description

(1S,4R)-4-[(2,5-Diamino-6-Chloro-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanol is a high-purity, chiral pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a sophisticated building block for the synthesis of complex nucleoside analogs and other bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of antiviral and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel nucleoside-based drug candidates.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents that interfere with DNA synthesis and repair.
• Biochemical Tool Compound: Employed in enzymatic studies and as a reference standard for analytical method development.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of specialty active molecules.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new chemical entities and structure-activity relationships.

Basic Information

Product Name	(1S,4R)-4-[(2,5-Diamino-6-Chloro-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanol
CAS No.	141271-11-6
Molecular Formula	C10H14ClN6O
Molecular Weight	269.71 g/mol
Synonyms	4-[(2,5-Diamino-6-chloro-4-pyrimidinyl)amino]-2-cyclopentene-1-methanol, (1S,4R)-; (1S,4R)-4-[(2,5-Diamino-6-chloro-4-pyrimidinyl)amino]-2-cyclopenten-1-ylmethanol; 2-Cyclopentene-1-methanol, 4-[(2,5-diamino-6-chloro-4-pyrimidinyl)amino]-, (1S,4R)-; 141271-11-6; (1S,4R)-4-[(2,5-Diamino-6-chloro-pyrimidin-4-yl)amino]-cyclopent-2-enyl-methanol; Chiral Cyclopentenyl Pyrimidine Intermediate; Abacavir Intermediate Derivative
EINECS	Contact for details

Quality Control

Our (1S,4R)-4-[(2,5-Diamino-6-Chloro-4-Pyrimidinyl)Amino]-2-Cyclopentene-1-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.