Description

Substance P, n-Spermine-Gln(5)- CAS NO 141231-59-6 is a synthetic peptide derivative of the neuropeptide Substance P, modified with a spermine moiety at the N-terminus and a glutamine at position 5. This specialized modification is designed to enhance its stability and interaction with specific biological targets, making it a valuable tool for advanced research in neurobiology and signal transduction. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in the study of neurokinin receptors, pain pathways, and cellular communication mechanisms.

Application

• Neuroscience Research: As a potent and modified neurokinin-1 (NK1) receptor ligand for studying pain signaling, inflammation, and emotional responses.
• Pharmacological Studies: Used in high-throughput screening and binding assays to identify and characterize novel analgesic or anti-inflammatory drug candidates.
• Cell Biology & Signal Transduction: Investigation of G-protein coupled receptor (GPCR) activation, intracellular calcium mobilization, and downstream effector pathways.
• Bioconjugation & Probe Development: The spermine moiety can serve as a handle for further chemical modification, labeling, or attachment to delivery systems for targeted research applications.
• Academic & Institutional R&D: A critical reagent for fundamental research into the role of Substance P in various physiological and pathological processes.

Basic Information

Product Name	Substance P, n-Spermine-Gln(5)-
CAS No.	141231-59-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	n-Spermine-Substance P (5-Gln); Spermine-Substance P analog; [Gln5]-Substance P, N-spermine derivative; Neurokinin P, modified; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (N-spermine); SP analog; NK1 receptor ligand analog; SP (5-11), N-spermine-Gln5-
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Substance P, n-Spermine-Gln(5)- undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.