Description

N4-((Diisopropylamino)Methylene)-2',3'-Dideoxycytidine is a chemically modified nucleoside derivative, specifically a cytidine analog, designed for advanced pharmaceutical research and development. This compound is a critical synthetic intermediate in the production of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral or anticancer therapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the synthesis of novel antiviral drugs, prodrug development, and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent nucleoside reverse transcriptase inhibitors (NRTIs) for antiviral therapies.
• Antiviral Drug Development: Serves as a precursor in the research and production of experimental drugs targeting HIV, HBV, and other viral infections.
• Medicinal Chemistry & SAR Studies: Used in structure-activity relationship studies to optimize the efficacy and pharmacokinetic properties of nucleoside analogs.
• Prodrug Synthesis: Employed in creating prodrug forms of antiviral agents to enhance bioavailability and targeted delivery.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies related to viral replication mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	N4-((Diisopropylamino)Methylene)-2',3'-Dideoxycytidine
CAS No.	141043-80-3
Molecular Formula	C16H26N4O3
Molecular Weight	322.41 g/mol
Synonyms	2',3'-Dideoxy-N4-((diisopropylamino)methylene)cytidine; DDC-N4-Diisopropylaminomethylene Derivative; N4-(Diisopropylaminomethylene)-2',3'-dideoxycytidine; 2',3'-Dideoxycytidine N4-(diisopropylaminomethylene) derivative; (2'R,3'S,5'R)-5-(4-((Diisopropylamino)methylene)amino)-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol (IUPAC); DDC amidine derivative; Anti-HIV nucleoside intermediate
EINECS	Contact for details

Quality Control

Our N4-((Diisopropylamino)Methylene)-2',3'-Dideoxycytidine is manufactured under strict quality systems suitable for pharmaceutical research. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development protocols. Specifications can be aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.