Description

Mu-Conotoxin Giiib is a highly selective and potent peptide neurotoxin derived from the venom of the marine cone snail *Conus geographus*. This compound matters as a critical research tool for its specific blockade of voltage-gated sodium channels, particularly the neuronal Nav1.2 subtype. It is primarily needed by pharmaceutical researchers, neuroscientists, and toxicologists for ion channel studies, neurological disorder research, and the development of novel analgesic and therapeutic agents.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and distribution of specific voltage-gated sodium channel subtypes (e.g., Nav1.2) in neuronal circuits.
• Drug Discovery & Development: Used in high-throughput screening and validation assays to identify and characterize new compounds targeting sodium channels for pain management, epilepsy, and cardiac arrhythmias.
• Toxicology Studies: Serves as a reference standard for understanding the mechanism of action of conotoxins and for assessing biological activity in venom research.
• Ion Channel Characterization: Essential for electrophysiology experiments (e.g., patch-clamp) to dissect the biophysical properties and subunit composition of sodium channels.
• Biochemical Assays: Used in binding studies and competitive displacement assays to investigate receptor-ligand interactions at sodium channel sites.
• Academic & Pharmaceutical R&D: Supports fundamental research into neurological pathways and the development of targeted neurotherapeutics with potentially fewer side effects.

Basic Information

Product Name	Mu-Conotoxin Giiib
CAS No.	140678-12-2
Molecular Formula	C97H149N33O30S7
Molecular Weight	~ 2280.8 g/mol
Synonyms	μ-Conotoxin GIIB; Mu-Conotoxin GIIIB; Conotoxin GIIB; Geographutoxin II; μ-CTX GIIB; Mu-CTX GIIB; Conus geographus toxin GIIB; μ-Conotoxin from Conus geographus
EINECS	Contact for details

Quality Control

Our Mu-Conotoxin Giiib is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and bioactivity data are available upon request to support your research compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into working solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity	Verified by functional assay (e.g., electrophysiology)
Solubility	Soluble in aqueous buffers (e.g., PBS, saline)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.