Description

3',5'-Difluoro-2'-Hydroxyacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique molecular structure, featuring both a phenolic hydroxyl and strategically placed fluorine atoms, makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluorophenol moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, where the fluorine atoms can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers or as a modifying agent for specialty materials requiring fluorinated aromatic components.
• Chemical Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3',5'-Difluoro-2'-Hydroxyacetophenone
CAS No.	140675-42-9
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	1-(2-Hydroxy-3,5-difluorophenyl)ethanone; 2'-Hydroxy-3',5'-difluoroacetophenone; 3,5-Difluoro-2-hydroxyacetophenone; 2-Acetyl-3,5-difluorophenol; Ethanone, 1-(2-hydroxy-3,5-difluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 3',5'-Difluoro-2'-Hydroxyacetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.