Description

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 CAS NO 140430-53-1 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound matters as a critical research tool for the specific detection and quantification of matrix metalloproteinase (MMP) activity, particularly collagenases like MMP-8 and MMP-13. Life science researchers and pharmaceutical developers need it for studying proteolytic pathways, screening enzyme inhibitors, and conducting biochemical research related to tissue remodeling, cancer metastasis, and inflammatory diseases.

Application

• Biochemical Research: As a specific fluorogenic substrate for the kinetic analysis and characterization of collagenase (MMP-8, MMP-13) activity.
• Drug Discovery & Screening: High-throughput screening (HTS) of potential therapeutic inhibitors targeting matrix metalloproteinases in pharmaceutical R&D.
• Enzyme Assay Development: A key component in developing sensitive and specific in vitro diagnostic assays for proteolytic enzymes.
• Academic Research: Used in university and institutional labs to investigate the role of MMPs in physiological and pathological processes such as wound healing, arthritis, and tumor progression.
• Biomarker Studies: Facilitating research into MMP activity as a potential biomarker in various disease states.

Basic Information

Product Name	Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2
CAS No.	140430-53-1
Molecular Formula	C52H76N16O15
Molecular Weight	1125.26 g/mol
Synonyms	Mca-PLGL-Dpa-AR-NH2; (7-Methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2; Fluorogenic MMP-8 Substrate; Fluorogenic MMP-13 Substrate; Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2; Collagenase Fluorogenic Substrate; MMP Substrate IV; Dnp-Dpa-PLGL-AR(Mca)-NH2
EINECS	Contact for details

Quality Control

Our Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is manufactured under strict quality systems suitable for research use. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.