Description

Cyclo(Leu-Leu-Trp-Glu-Ala) is a synthetic cyclic pentapeptide composed of the amino acids leucine, tryptophan, glutamic acid, and alanine. This specific structural motif is of significant interest in pharmaceutical and biochemical research for its potential to modulate protein-protein interactions and biological signaling pathways. It serves as a critical building block and reference standard for researchers in medicinal chemistry, peptide synthesis, and drug discovery.

Application

• Pharmaceutical Research & Development: Used as a key intermediate or reference standard in the discovery and development of novel peptide-based therapeutics.
• Biochemical Studies: Employed as a model compound to study cyclic peptide conformation, stability, and receptor binding affinity.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Academic Research: Utilized in university and institutional labs for investigating peptide synthesis methodologies and biological mechanisms.
• Peptide Library Synthesis: Acts as a specialized component in the construction of focused peptide libraries for high-throughput screening.

Basic Information

Product Name	Cyclo(Leu-Leu-Trp-Glu-Ala)
CAS No.	140374-62-5
Molecular Formula	C33H46N6O7
Molecular Weight	638.76 g/mol
Synonyms	Cyclo(L-leucyl-L-leucyl-L-tryptophyl-L-α-glutamyl-L-alanyl); Cyclo(Leu-Leu-Trp-Glu-Ala) pentapeptide; c(LLWEA); Cyclopentapeptide LLWEA; H-c(Leu-Leu-Trp-Glu-Ala)-OH; Cyclo(L-Leu-L-Leu-L-Trp-L-Glu-L-Ala); 140374-62-5; Cyclo(Leu-Leu-Trp-Glu-Ala) CAS NO 140374-62-5
EINECS	Contact for details

Quality Control

Our Cyclo(Leu-Leu-Trp-Glu-Ala) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.