Description

Propanoic Acid, 2,2-Dimethyl-, (7-Bromo-2,6-Dimethyl-4-Oxo-3(4H)-Quinazolinyl)Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic quinazolinone structure. This compound is of significant value in medicinal chemistry for the synthesis of novel drug candidates, particularly those targeting specific enzymatic pathways. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new active pharmaceutical ingredients (APIs), especially those with quinazolinone-based structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with potential biological activity.
• Protease Inhibitor Development: Serves as a precursor or core structure in the design of enzyme inhibitors for therapeutic applications.
• Chemical Reference Standard: Employed as an analytical standard in quality control and method development for pharmaceutical analysis.
• Organic Synthesis: Utilized in multi-step synthetic routes to create more complex molecules for biological screening and evaluation.

Basic Information

Product Name	Propanoic Acid, 2,2-Dimethyl-, (7-Bromo-2,6-Dimethyl-4-Oxo-3(4H)-Quinazolinyl)Methyl Ester
CAS No.	140373-65-5
Molecular Formula	C₁₆H₁₉BrN₂O₃
Molecular Weight	367.24 g/mol
Synonyms	(7-Bromo-2,6-dimethyl-4-oxo-3,4-dihydroquinazolin-3-yl)methyl 2,2-dimethylpropanoate; Pivalic Acid (7-Bromo-2,6-Dimethyl-4-Oxo-3,4-Dihydroquinazolin-3-yl)Methyl Ester; 3-(Pivaloyloxymethyl)-7-bromo-2,6-dimethylquinazolin-4(3H)-one; 7-Bromo-2,6-dimethyl-3-(pivaloyloxymethyl)quinazolin-4(3H)-one; 140373-65-5; Quinazolinone pivalate ester; Bromoquinazolinone pivalate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.