Description

(S)-(-)-5-Iodowillardiine is a high-purity, non-natural amino acid derivative and a potent, subtype-selective agonist for kainate receptors, specifically GluK1. This compound matters significantly for advancing neurological research, as it serves as a critical pharmacological tool for studying glutamate receptor function, synaptic transmission, and excitotoxicity. It is primarily needed by research scientists and pharmaceutical developers in the fields of neuroscience, pharmacology, and medicinal chemistry for target validation and drug discovery programs.

Application

• Neuroscience Research: As a selective GluK1 (GluR5) kainate receptor agonist for electrophysiological studies and receptor characterization.
• Pharmacological Studies: Used in vitro and in vivo to investigate the role of kainate receptors in synaptic plasticity, pain pathways, and neurological disorders.
• Medicinal Chemistry: A key reference standard and building block for the design and synthesis of novel neuroactive compounds targeting glutamate receptors.
• Biochemical Assay Development: Employed as a standard ligand in binding assays (e.g., radioligand binding) and high-throughput screening (HTS) campaigns.
• Toxicology Research: Used to model excitotoxic neuronal injury and study mechanisms of cell death relevant to stroke and neurodegenerative diseases.

Basic Information

Product Name	(S)-(-)-5-Iodowillardiine
CAS No.	140187-25-3
Molecular Formula	C7H6IN3O4
Molecular Weight	323.04 g/mol
Synonyms	(S)-5-Iodowillardiine; (S)-5-Iodo-1,2-dihydro-4H-pyrrolo[3,4-d]pyrimidine-4,6(5H)-dione; (S)-5-Iodowillardine; (S)-(-)-5-Iodowillardine; 5-Iodo-L-willardiine; Iodowillardiine; GluK1 agonist; Kainate receptor agonist 5-Iodowillardiine
EINECS	Contact for details

Quality Control

Our (S)-(-)-5-Iodowillardiine is manufactured under strict quality controls to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.