Description

(S)-(-)-5-Fluorowillardiine is a high-purity, enantiomerically pure fluorinated derivative of the natural neuroactive amino acid willardiine. This compound is a potent and selective agonist for specific glutamate receptor subtypes, making it a critical research tool in neuroscience and pharmacology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers for receptor characterization, neurological disease modeling, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective agonist for kainate and AMPA subtypes of ionotropic glutamate receptors (GluK1, GluA1-4).
• Pharmacological Studies: For investigating excitatory synaptic transmission, neuronal excitability, and the mechanisms of neurodegenerative diseases.
• Drug Discovery & Development: Serving as a key reference standard and pharmacophore in the design of new neuroprotective or neuromodulatory compounds.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and binding assays to identify and characterize receptor modulators.
• Toxicology & Safety Pharmacology: Employed in studies to understand excitotoxicity and evaluate the neurotoxic potential of chemicals.
• Academic & Institutional Research: A fundamental tool for graduate and post-doctoral research in molecular neurobiology and cellular physiology.

Basic Information

Product Name	(S)-(-)-5-Fluorowillardiine
CAS No.	140187-23-1
Molecular Formula	C7H8FN3O4
Molecular Weight	217.16 g/mol
Synonyms	(S)-5-Fluorowillardiine; (S)-5-Fluoro-1,2,3,6-tetrahydropyrimidine-2,4-dione-6-carboxylic acid; 5-Fluoro-L-willardiine; (S)-2-Amino-5-fluoropyrimidine-4,6(1H,5H)-dione-6-acetic acid; 5-Fluorowillardiine (S-enantiomer); Fluorowillardiine; Willardiine, 5-fluoro-, (S)-; Selective GluK1/Kainate receptor agonist
EINECS	Contact for details

Quality Control

Our (S)-(-)-5-Fluorowillardiine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with every shipment to guarantee traceability and reproducibility for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.