Description

Bombesin (6-14), D-Trp(6)-Leu(13)-Psi(Ch2Nh)-Leu(14)- is a synthetic, biologically active peptide analog derived from the C-terminal fragment of the natural bombesin peptide. This compound is a potent and selective antagonist for the gastrin-releasing peptide receptor (GRPR), making it a critical research tool for studying neuroendocrine signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurobiology, and metabolic disorder research. The product is supplied under stringent quality control to ensure batch-to-batch consistency for reliable experimental results.

Application

• Biomedical Research: Used as a specific GRPR antagonist to investigate receptor function, signal transduction, and cellular proliferation in cancer models.
• Oncology Studies: Essential for probing the role of bombesin-like peptides in tumor growth, particularly in prostate, breast, and small-cell lung cancers.
• Neuropharmacology: Applied in studies of central nervous system disorders, appetite regulation, and stress responses mediated by bombesin receptors.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel therapeutic agents targeting GRPR.
• In Vitro Diagnostics: Utilized in assay development and validation for receptor binding studies and high-throughput screening.
• Academic & Institutional Research: A key reagent for fundamental research in peptide chemistry, endocrinology, and molecular biology.

Basic Information

Product Name	Bombesin (6-14), D-Trp(6)-Leu(13)-Psi(Ch2Nh)-Leu(14)-
CAS No.	140163-54-8
Molecular Formula	C57H83N15O10
Molecular Weight	1126.4 g/mol
Synonyms	D-Trp6,Leu13ψ(CH2NH)Leu14-Bombesin(6-14); [D-Trp6,Leu13ψ(CH2NH)Leu14]-Bombesin(6-14); Bombesin Receptor Antagonist; GRP Receptor Antagonist; RC-3095; (6-14)-Bombesin, D-Tryptophan-6,Leucine-13-(methylenamino)leucine-14-; D-Trp6,Leu13-psi(CH2NH)-Leu14-bombesin(6-14)
EINECS	Contact for details

Quality Control

Our Bombesin (6-14), D-Trp(6)-Leu(13)-Psi(Ch2Nh)-Leu(14)- is manufactured under controlled conditions to meet the exacting standards of research-grade peptides. Each batch undergoes rigorous analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, content, and analytical results. Our quality system ensures compliance with relevant guidelines for research chemicals, providing the consistency required for reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.