Description

Fmoc-β-Ala-Val-Oh CAS NO 139928-72-6 is a protected dipeptide building block, specifically an Fmoc-protected derivative of β-alanine and L-valine, widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise control. It is an essential raw material for pharmaceutical R&D, particularly in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the sequential assembly of custom peptide chains on resin supports.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel therapeutic peptide candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Incorporates a β-amino acid spacer (β-Ala) to modify peptide backbone structure and enhance metabolic stability or bioavailability.
• Bioconjugation & Probe Synthesis: Serves as a linker or intermediate for attaching peptides to other molecules, surfaces, or reporter tags.
• Academic & Contract Research: A standard reagent in university labs and CROs (Contract Research Organizations) for biochemical and medicinal chemistry studies.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	Fmoc-β-Ala-Val-Oh
CAS No.	139928-72-6
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	Fmoc-β-Ala-Val-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanyl-L-valine; Fmoc-β-alanyl-L-valine; Fmoc-β-alanyl-L-valine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoic acid; Fmoc-βAla-Val-OH; Fmoc-β-alanine-valine; N-Fmoc-β-alanyl-L-valine
EINECS	Contact for details

Quality Control

Our Fmoc-β-Ala-Val-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with cGMP guidelines for pharmaceutical intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Valine)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.