Description

Benzenamine, 2-(Difluoromethoxy)-6-Methyl- is a specialized fluorinated aniline derivative, a key building block in advanced organic synthesis. Its molecular structure, featuring a difluoromethoxy substituent, is engineered to impart unique electronic and steric properties, enhancing the performance of final compounds. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients with improved efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry and process chemistry R&D, enabling structure-activity relationship (SAR) studies and route optimization.
• Fluorine Chemistry Building Block: Exploited in organofluorine chemistry to introduce the metabolically stable difluoromethoxy moiety into complex molecules.

Basic Information

Item	Details
Product Name	Benzenamine, 2-(Difluoromethoxy)-6-Methyl-
CAS No.	139909-66-3
Molecular Formula	C8H9F2NO
Molecular Weight	173.16 g/mol
Synonyms	2-(Difluoromethoxy)-6-methylaniline; 2-Methyl-6-(difluoromethoxy)aniline; 6-Methyl-2-(difluoromethoxy)benzenamine; 2-Amino-3-methylphenyl difluoromethyl ether; α,α-Difluoro-2-amino-m-cresol methyl ether
EINECS	Contact for details

Quality Control

Every batch of Benzenamine, 2-(Difluoromethoxy)-6-Methyl- is manufactured and tested under a strict quality management system. We ensure high chemical purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your precise R&D or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.