Description

Fmoc-Aib-Aib-Oh CAS NO 139881-77-9 is a specialized, high-purity dipeptide building block featuring two consecutive α-aminoisobutyric acid (Aib) residues protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is critical for constructing peptide helices and foldamers with enhanced conformational stability, making it an essential tool in advanced peptide research and development. It is primarily utilized by pharmaceutical researchers, biochemists, and CROs focused on developing novel therapeutic peptides, peptidomimetics, and materials with precise structural properties.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the iterative synthesis of complex peptides containing Aib residues.
• Peptidomimetic Drug Discovery: Used to introduce rigid, helical structures into peptide backbones to enhance metabolic stability, bioavailability, and target binding affinity.
• Foldamer Research: Essential for constructing artificial oligomers and foldamers that mimic protein secondary structures for biochemical studies and material science.
• Antimicrobial Peptide (AMP) Development: Incorporated to engineer peptides with stabilized helical conformations for improved antimicrobial activity and selectivity.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptide probes for diagnostic and imaging applications.
• Academic and Industrial R&D: A fundamental reagent in laboratories investigating protein folding, structure-activity relationships (SAR), and novel biomaterials.

Basic Information

Product Name	Fmoc-Aib-Aib-Oh
CAS No.	139881-77-9
Molecular Formula	C24H26N2O5
Molecular Weight	422.48 g/mol
Synonyms	Fmoc-α-aminoisobutyryl-α-aminoisobutyric acid; N-(9-Fluorenylmethoxycarbonyl)-α-aminoisobutyryl-α-aminoisobutyric acid; Fmoc-Aib-Aib-OH; Fmoc-Aib2-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylalanyl-2-methylalanine; (2R)-2-[[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-methylpropanoyl]amino]-2-methylpropanoic acid; Fmoc-D-Aib-D-Aib-OH (for enantiomeric form); Fmoc-protected Aib dipeptide
EINECS	Contact for details

Quality Control

Our Fmoc-Aib-Aib-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific research or cGMP guidelines for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.