Description

Fmoc-Cys(Pam)2-Oh (R) is a high-purity, orthogonally protected cysteine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity and deprotection sequences, enabling the construction of complex peptides and proteins. It is an essential building block for the pharmaceutical, biotechnology, and life science research industries, particularly in the development of therapeutic peptides and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the Fmoc/t-Bu strategy, facilitating the sequential assembly of peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Labeling: The protected thiol group allows for site-specific modification of peptides with fluorophores, polymers, or other functional molecules.
• Protein Engineering: Enables the site-directed incorporation of cysteine analogs into synthetic or semi-synthetic proteins.
• Chemical Biology Research: A vital tool for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).
• Production of Cysteine-rich Peptides: Essential for the synthesis of peptides containing multiple disulfide bonds, such as hormones and antimicrobial peptides.

Basic Information

Product Name	Fmoc-Cys(Pam)2-Oh (R)
CAS No.	139573-77-6
Molecular Formula	C32H35NO6S
Molecular Weight	561.69 g/mol
Synonyms	Fmoc-Cys(Pam)2-OH; Fmoc-Cys(Pam)2-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(phenylmethyl)-L-cysteine; Fmoc-S-benzyl-L-cysteine; Fmoc-Cys(Bzl)-OH; Nα-Fmoc-S-benzyl-L-cysteine; Fmoc-L-Cys(Bzl)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(benzylthio)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Pam)2-Oh (R) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistent enantiomeric excess, meeting the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and compliance with research and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.