Description

Fmoc-2-Aminoethanethioic S-Acid CAS NO 139448-92-3 is a specialized Fmoc-protected thioic acid derivative, a crucial building block in modern organic synthesis. This compound is valued for its role in facilitating the controlled introduction of thioamide and related functional groups, enabling the development of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for peptide mimetics, drug discovery, and catalyst ligand synthesis.

Application

• Peptide Mimetics & Drug Discovery: A key intermediate for synthesizing thioamide-containing peptide analogs, which can enhance metabolic stability and binding affinity in therapeutic candidates.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc-based SPPS protocols for the site-specific incorporation of thioic acid or thioamide functionalities.
• Organocatalyst & Ligand Synthesis: Serves as a precursor for constructing novel ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Chemical Biology Probes: Employed in the development of activity-based probes and bioconjugation reagents to study enzyme function and protein interactions.
• Agrochemical Research: Used as a building block in the synthesis of novel active ingredients with potential pesticidal or herbicidal activity.
• Material Science: A monomer or cross-linking agent in the development of functional polymers and advanced organic materials.

Basic Information

Product Name	Fmoc-2-Aminoethanethioic S-Acid
CAS No.	139448-92-3
Molecular Formula	C₁₇H₁₅NO₃S
Molecular Weight	313.37 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminoethanethioic S-acid; Fmoc-AETA; 2-[(9-Fluorenylmethoxycarbonyl)amino]ethanethioic S-acid; Fmoc-NH-CH2-C(O)SH; N-Fmoc-2-mercaptoacetamide; Fmoc-protected 2-aminoethanethioic acid; N-(9-Fluorenylmethoxycarbonyl)-2-aminoethanethioic acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Aminoethanethioic S-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.