Description

(2R,4S)-n-α-(9-Fluorenylmethoxycarbonyl)-4-Hydroxypyrrolidine-2-Carboxylic Acid is a high-purity, chiral Fmoc-protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for constructing complex peptides and peptidomimetics with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including protease inhibitors and other bioactive molecules. Its defined stereochemistry at the 2 and 4 positions ensures the production of peptides with the intended three-dimensional structure and biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral building block for the Fmoc-strategy synthesis of complex peptides.
• Pharmaceutical Intermediates: Used in the research and development of novel drug candidates, particularly protease inhibitors and other targeted therapies.
• Peptidomimetics Design: Integral for creating stable, bioavailable mimics of natural peptides for medicinal chemistry applications.
• Biochemical Research: Employed in studies of enzyme-substrate interactions and structure-activity relationships (SAR).
• Combinatorial Chemistry Libraries: Serves as a valuable component for generating diverse libraries of chiral compounds for high-throughput screening.

Basic Information

Product Name	(2R,4S)-n-α-(9-Fluorenylmethoxycarbonyl)-4-Hydroxypyrrolidine-2-Carboxylic Acid
CAS No.	139262-20-7
Molecular Formula	C20H19NO5
Molecular Weight	353.37 g/mol
Synonyms	Fmoc-(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic Acid; (2R,4S)-Fmoc-4-Hydroxyproline; (2R,4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic Acid; Fmoc-cis-4-Hydroxy-D-proline; Fmoc-D-Hyp-OH; (2R,4S)-4-Hydroxy-1-[(9-fluorenylmethoxy)carbonyl]pyrrolidine-2-carboxylic Acid; (2R,4S)-N-Fmoc-4-hydroxyproline
EINECS	Contact for details

Quality Control

Our (2R,4S)-Fmoc-4-Hydroxyproline is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for sensitive pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to industry best practices, and specifications can be tailored to meet specific research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.