Description

Nα-(9-Fluorenemethoxycarbonyl)-L-Homocysteine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled incorporation of homocysteine into peptide chains while preventing unwanted side reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates for therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the stepwise construction of custom peptides.
• Peptide Drug Discovery: Used in research to synthesize peptide libraries for screening biological activity and drug candidate optimization.
• Bioconjugation: The homocysteine moiety can be utilized for site-specific labeling or attachment to other molecules, such as polymers or surfaces, via its thiol group after deprotection.
• Chemical Biology Research: Employed in studies investigating protein structure-function relationships, enzyme mechanisms, and metabolic pathways involving sulfur-containing amino acids.
• Material Science: Can be incorporated into synthetic peptides designed for creating novel biomaterials or hydrogels.

Basic Information

Product Name	Nα-(9-Fluorenemethoxycarbonyl)-L-Homocysteine
CAS No.	139224-85-4
Molecular Formula	C20H21NO4S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-Hcy-OH; Fmoc-L-Homocysteine; N-Fmoc-L-homocysteine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-sulfanylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-homocysteine; L-Homocysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-homocysteine
EINECS	Contact for details

Quality Control

Our Nα-(9-Fluorenemethoxycarbonyl)-L-Homocysteine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.