Description

Boc-Pna-T-Oh CAS NO 139166-80-6 is a protected amino acid derivative, specifically a Boc-protected para-nitroaniline derivative with a terminal carboxylic acid group, serving as a crucial building block in organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the construction of complex peptides, peptidomimetics, and other bioactive molecules. It is primarily utilized by the pharmaceutical, biotechnology, and advanced materials sectors for research, development, and scale-up production.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce specific aromatic and protected amine functionalities into peptidomimetic scaffolds for drug discovery programs.
• Bioconjugation: Serves as a linker or spacer molecule in the conjugation of peptides to other biomolecules, polymers, or surfaces for diagnostic and therapeutic applications.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides and activity-based probes for studying enzyme function and protein-protein interactions.
• Material Science: Acts as a monomer or functionalization agent in the synthesis of specialized polymers and smart materials.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	Boc-Pna-T-Oh
CAS No.	139166-80-6
Molecular Formula	C12H16N2O5
Molecular Weight	268.27 g/mol
Synonyms	tert-Butyl (4-nitro-1-oxo-1-(p-tolylamino)pentan-2-yl)carbamate; Boc-4-Nitro-DL-phenylalanine-4-methylanilide; Boc-PNA(4-NO2)-T-OH; N-(tert-Butoxycarbonyl)-4-nitro-DL-phenylalanyl-p-toluidide; Boc-4-Nitrophenylalanine-p-toluidide; BOC-PNA(4-NO2)-TOLUIDIDE; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(4-nitrophenyl)-N-(p-tolyl)propionamide
EINECS	Contact for details

Quality Control

Our Boc-Pna-T-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.