Description

Proto-Oncogene Protein C-Cbl CAS NO 139076-33-8 is a high-purity, recombinant protein that serves as a critical E3 ubiquitin ligase involved in intracellular signal transduction pathways. This protein is essential for research into cellular regulation, protein degradation, and oncogenic signaling mechanisms. It is primarily utilized by academic, pharmaceutical, and biotechnology research institutions for biochemical assays, target validation, and drug discovery programs focused on cancer and immune system disorders.

Application

• Biochemical Research: Used as a key reagent in in vitro ubiquitination assays to study enzyme kinetics and substrate specificity.
• Signal Transduction Studies: Essential for investigating the regulation of receptor tyrosine kinase (RTK) pathways and downstream effector molecules.
• Drug Discovery & Target Validation: Serves as a critical tool for screening and validating novel therapeutic compounds that modulate E3 ligase activity in oncology research.
• Protein-Protein Interaction Analysis: Employed in pull-down assays, co-immunoprecipitation (Co-IP), and surface plasmon resonance (SPR) to map interaction networks.
• Cell Biology & Functional Genomics: Used in cellular transfection and functional studies to understand the role of C-Cbl in cell growth, differentiation, and apoptosis.
• Reference Standard Production: Acts as a purified standard for the development and calibration of diagnostic assays and analytical methods.

Basic Information

Product Name	Proto-Oncogene Protein C-Cbl CAS NO 139076-33-8
CAS No.	139076-33-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Casitas B-lineage Lymphoma Proto-Oncogene; C-CBL; RING Finger Protein 55; RNF55; Proto-Oncogene c-Cbl; Signal Transduction Protein CBL; E3 Ubiquitin-Protein Ligase CBL; CBL2; C-Cbl Protein; Recombinant Human C-Cbl Protein
EINECS	Contact for details

Quality Control

Our Proto-Oncogene Protein C-Cbl is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, verification of identity by mass spectrometry, and functional activity assays. Certificates of Analysis (COA) detailing purity, concentration, endotoxin levels, and specific activity are provided and available upon request, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Identification (Mass Spectrometry)	Conforms
Protein Concentration	As per COA
Biological Activity (Ubiquitination Assay)	Active
Endotoxin Level	< 1.0 EU/µg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.