Description

6-Amino-3-(Prop-2-Ynyl)Pyrimidine-2,4(1H,3H)-Dione is a specialized heterocyclic building block featuring a uracil core modified with an amino group and a propargyl substituent. This unique molecular architecture makes it a critical intermediate for the synthesis of novel nucleoside analogs and other bioactive compounds. It is primarily required by pharmaceutical R&D and fine chemical synthesis teams focused on developing antiviral and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral (e.g., anti-HIV, anti-HCV) and anticancer drug discovery programs.
• Bioconjugation & Click Chemistry: The propynyl group serves as a handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the labeling and modification of biomolecules.
• Agrochemical Research: Used as a building block for developing new pesticides and herbicides with targeted modes of action.
• Chemical Biology Probes: Synthesis of activity-based probes and diagnostic agents for studying enzymatic processes related to nucleotide metabolism.
• Academic & Contract Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential monomer or modifier for creating functional polymers with specific recognition or catalytic properties.

Basic Information

Product Name	6-Amino-3-(Prop-2-Ynyl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	138895-22-4
Molecular Formula	C7H7N3O2
Molecular Weight	165.15 g/mol
Synonyms	6-Amino-3-propargyluracil; 3-Propargyl-6-aminouracil; 6-Amino-1H-pyrimidine-2,4-dione, 3-(2-propynyl)-; APU; 6-Amino-3-(2-propynyl)-1H-pyrimidine-2,4-dione; 138895-22-4; 6-Amino-3-prop-2-ynyl-1H-pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 6-Amino-3-(Prop-2-Ynyl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.