Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(5-Methyl-2,5-Diazabicyclo[2.2.1]Hept-2-Yl)-4-Oxo-, (1R)-, Monomethanesulfonate (9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex, chiral molecular structure. This compound is of critical importance for its role as a key building block in the synthesis of novel antibacterial agents, particularly fluoroquinolone derivatives. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antibiotics targeting resistant bacterial strains.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of advanced fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new antibacterial compounds with improved efficacy and safety profiles.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for clinical trial material and commercial manufacturing.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in drug development pipelines.

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(5-Methyl-2,5-Diazabicyclo[2.2.1]Hept-2-Yl)-4-Oxo-, (1R)-, Monomethanesulfonate (9Ci)
CAS No.	138874-49-4
Molecular Formula	C19H22FN3O5S
Molecular Weight	423.46 g/mol
Synonyms	(1R)-1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinolinecarboxylic acid monomethanesulfonate; (R)-Ofloxacin mesylate derivative; 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-((5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl))-4-oxo-3-quinolinecarboxylic acid methanesulfonate (1:1); Advanced Ofloxacin intermediate; Chiral quinolone carboxylic acid salt; Pharma intermediate 138874-49-4.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(5-Methyl-2,5-Diazabicyclo[2.2.1]Hept-2-Yl)-4-Oxo-, (1R)-, Monomethanesulfonate (9Ci) is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.