Description

Fmoc-5-Fluoro-Dl-Tryptophan is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers developing novel peptide-based pharmaceuticals and biochemical tools, as the fluorine substitution and Fmoc-protection offer unique reactivity and stability profiles. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on peptide chemistry, drug discovery, and proteomics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected building block for the automated synthesis of custom peptides containing fluorinated tryptophan analogs.
• Pharmaceutical Research: Incorporation into peptide drug candidates to study the effects of fluorination on bioactivity, metabolic stability, and receptor binding affinity.
• Biochemical Probe Development: Synthesis of labeled or modified peptides used as probes in enzyme studies, protein-protein interaction assays, and structural biology (e.g., NMR, fluorescence studies).
• Peptide Library Construction: A key component in combinatorial chemistry for creating diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Contract Research: Fundamental research tool in university and CRO settings for exploring novel peptide architectures and unnatural amino acid applications.

Basic Information

Product Name	Fmoc-5-Fluoro-Dl-Tryptophan
CAS No.	138775-55-0
Molecular Formula	C₂₆H₂₁FN₂O₄
Molecular Weight	444.46 g/mol
Synonyms	Fmoc-5-F-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-fluoro-DL-tryptophan; 5-Fluoro-DL-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-5-fluoro-DL-tryptophan; Fmoc-5-Fluoro-DL-Trp; 5-Fluoro-DL-tryptophan Fmoc derivative; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-5-Fluoro-Dl-Tryptophan is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and development-phase pharmaceutical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.