Description

Fmoc-5-Methoxy-Dl-Tryptophan CAS NO 138775-54-9 is a protected, non-natural amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled incorporation of a methoxy-modified tryptophan residue into peptide chains, which is essential for research into peptide structure-activity relationships and drug discovery. This compound is particularly vital for pharmaceutical R&D scientists, biochemists, and CROs developing novel therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of custom peptide sequences in automated synthesizers.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including antimicrobial peptides and hormone analogs.
• Biochemical Probe Development: Incorporation into peptides designed to study enzyme-substrate interactions, receptor binding, and cellular signaling pathways.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying peptide backbones to investigate the impact of tryptophan modification on biological activity, stability, and pharmacokinetics.
• Academic Research: Employed in university and institutional labs for fundamental research in peptide chemistry and molecular biology.
• Contract Research & Manufacturing (CRO/CMO): A standard reagent for organizations providing custom peptide synthesis services to the biotech and pharmaceutical industries.

Basic Information

Product Name	Fmoc-5-Methoxy-Dl-Tryptophan
CAS No.	138775-54-9
Molecular Formula	C₂₉H₂₈N₂O₅
Molecular Weight	484.55 g/mol
Synonyms	Fmoc-5-MeO-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methoxy-DL-tryptophan; 5-Methoxy-DL-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-5-methoxy-DL-tryptophan; N-Fmoc-5-methoxy-DL-tryptophan; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid; DL-5-Methoxytryptophan, N-Fmoc-; Fmoc-DL-5-methoxytryptophan
EINECS	Contact for details

Quality Control

Our Fmoc-5-Methoxy-Dl-Tryptophan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with client requirements for advanced pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.