Description

n-Fmoc-3-Hydroxy-Dl-Phenylalanine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of a tyrosine-like phenolic hydroxyl group into peptide chains, enabling advanced research in medicinal chemistry and biochemistry. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions developing novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the stepwise construction of complex peptides containing non-natural amino acids.
• Medicinal Chemistry Research: Used in the design and synthesis of peptide analogs, enzyme inhibitors, and receptor ligands targeting various disease pathways.
• Bioconjugation and Probe Development: The phenolic hydroxyl group, after deprotection, provides a handle for site-specific labeling with fluorescent dyes, biotin, or other functional moieties.
• Combinatorial Library Synthesis: Employed in generating diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Biochemical Studies: Useful for investigating protein-protein interactions, signal transduction, and post-translational modifications by incorporating modified tyrosine residues.

Basic Information

Product Name	n-Fmoc-3-Hydroxy-Dl-Phenylalanine
CAS No.	138775-49-2
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-3-hydroxy-DL-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-DL-phenylalanine; 3-Hydroxy-DL-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-Tyr(3-OH)-OH (DL); N-Fmoc-3-hydroxy-DL-phenylalanine; DL-3-Hydroxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]phenylalanine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Hydroxy-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.