Description

Fmoc-n-Methyl-L-Isoleucine CAS NO 138775-22-1 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique, sterically hindered N-methyl-isoleucine residue into peptide chains, a modification known to enhance metabolic stability and modulate biological activity. It is an essential building block for pharmaceutical researchers and manufacturers developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Peptide Drug Discovery & Development: A key raw material for synthesizing complex peptide libraries and candidate molecules targeting GPCRs, enzymes, and other biological targets.
• Synthesis of N-Methylated Peptides: Specifically used to incorporate N-methyl-isoleucine, a modification that improves peptide membrane permeability, proteolytic resistance, and oral bioavailability.
• Production of Peptide Hormones and Cytokines: Enables the construction of analogs with enhanced potency and duration of action for therapeutic applications.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides used in imaging, diagnostic assays, and targeted drug delivery systems.
• Academic & Industrial Research: Used in biochemical studies to investigate protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR).
• Combinatorial Chemistry: A valuable component in automated synthesizers for generating diverse peptide arrays for high-throughput screening.

Basic Information

Product Name	Fmoc-n-Methyl-L-Isoleucine
CAS No.	138775-22-1
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-N-Me-Ile-OH; Fmoc-N-methyl-L-isoleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-isoleucine; (2S,3S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-3-methylpentanoic acid; Fmoc-MeIle-OH; Nα-Fmoc-Nα-methyl-L-isoleucine; Fmoc-N-methylisoleucine; N-Fmoc-N-methyl-L-isoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-L-Isoleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.