Description

Fmoc-Orn(Z)-Oh CAS NO 138775-07-2 is a protected amino acid derivative, specifically an N-α-Fmoc and N-δ-Cbz protected L-ornithine, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides by providing orthogonal protection for the side-chain amine, which is essential for synthesizing peptides containing ornithine residues. This high-purity intermediate is indispensable for researchers and manufacturers in pharmaceutical development, bioconjugation, and the production of therapeutic peptides and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of peptides containing ornithine.
• Pharmaceutical Intermediates: Used in the research and development of novel peptide-based drugs and APIs.
• Bioconjugation and Linker Chemistry: The reactive side-chain, when deprotected, is utilized for attaching peptides to other molecules, surfaces, or carriers.
• Research & Development: Essential for academic and industrial labs studying peptide structure-activity relationships (SAR).
• Synthesis of Branched and Cyclic Peptides: The ornithine side chain provides a branching point for constructing complex peptide architectures.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Item	Detail
Product Name	Fmoc-Orn(Z)-Oh
CAS No.	138775-07-2
Molecular Formula	C₂₈H₂₈N₂O₆
Molecular Weight	488.53 g/mol
Synonyms	Fmoc-L-Orn(Z)-OH; N-α-Fmoc-N-δ-Cbz-L-ornithine; N-δ-(Benzyloxycarbonyl)-N-α-(9-fluorenylmethoxycarbonyl)-L-ornithine; Fmoc-Orn(Cbz)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((benzyloxy)carbonyl)amino)pentanoic acid; Fmoc-Orn(Boc)-OH (common mis-assignment); N-α-Fmoc-N-ω-Cbz-L-ornithine; Fmoc-Orn(Z)
EINECS	Contact for details

Quality Control

Our Fmoc-Orn(Z)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed specifications for assay, optical rotation, and impurity profile are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.