Description

Fmoc-3-(2-Naphthyl)-D-Alanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters for its role in constructing complex peptides with enhanced stability and specific biological activity, particularly where the bulky, hydrophobic 2-naphthyl side chain is required. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies engaged in the discovery of novel therapeutic peptides, peptidomimetics, and as a building block for advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of custom peptides with a hydrophobic aromatic moiety.
• Pharmaceutical Research: Used in the development of peptide-based drug candidates, enzyme inhibitors, and receptor ligands targeting various diseases.
• Peptidomimetic Design: Incorporation into non-natural peptide backbones to improve metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and cellular processes.
• Material Science: Potential use in the creation of self-assembling peptide nanostructures and biomaterials.

Basic Information

Product Name	Fmoc-3-(2-Naphthyl)-D-Alanine
CAS No.	138774-94-4
Molecular Formula	C28H23NO4
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-D-2-Nal-OH; Fmoc-3-(2-Naphthyl)-D-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-naphthyl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-2-yl)propanoic acid; Fmoc-D-2-Naphthylalanine; N-α-Fmoc-3-(2-naphthyl)-D-alanine; Fmoc-D-Nal(2)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-3-(2-Naphthyl)-D-Alanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.