Description

Fmoc-D-1-Naphthylalanine CAS NO 138774-93-3 is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This chiral building block is critical for introducing the bulky, hydrophobic 1-naphthyl side chain of the D-configuration into peptide sequences, enabling the creation of novel structures with enhanced stability and biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research & Development: Used to incorporate D-1-naphthylalanine residues into peptide drug candidates to modulate pharmacokinetics, receptor binding affinity, and metabolic stability.
• Peptidomimetics & Conformation Studies: Essential for designing peptide analogs and studying structure-activity relationships (SAR) due to its rigid, aromatic side chain.
• Biochemical Probe Development: Serves as a key component in synthesizing labeled or modified peptides for use in assays, imaging, and diagnostic applications.
• Antibiotic & Antimicrobial Peptide Design: Employed in the synthesis of novel antimicrobial peptides where hydrophobic and bulky residues are crucial for membrane interaction.

Basic Information

Product Name	Fmoc-D-1-Naphthylalanine
CAS No.	138774-93-3
Molecular Formula	C₂₈H₂₃NO₄
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-D-1-Nal-OH; Fmoc-D-Nal(1)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-1-naphthylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic acid; Fmoc-D-Nap-OH; Fmoc-D-α-(1-Naphthyl)alanine; N-Fmoc-D-1-naphthylalanine; Fmoc-D-Nph-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-1-Naphthylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive peptide synthesis. A Certificate of Analysis (COA) detailing specific results for identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.