Description

5-Methyl-D-Norleucine is a non-proteinogenic D-amino acid derivative characterized by its unique branched-chain structure. This compound is of significant value in pharmaceutical research and development, particularly for its role as a chiral building block and metabolic probe. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, metabolic studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Metabolic Research: Used as a stable, non-metabolizable analog to study amino acid transport and metabolism in biological systems.
• Peptide Chemistry: Incorporated into custom peptides to modulate structure, stability, and biological activity for research purposes.
• Biochemical Tool: Serves as a substrate or inhibitor in enzymatic assays to study enzyme specificity and function.
• Nutritional Science Research: Investigated for its effects on protein synthesis and metabolic pathways in experimental models.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the synthesis of other chiral compounds.

Basic Information

Product Name	5-Methyl-D-Norleucine
CAS No.	138751-02-7
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	D-2-Amino-5-methylhexanoic acid; (R)-2-Amino-5-methylhexanoic acid; D-5-Methylnorleucine; D-5-Methyl-2-aminocaproic acid; (R)-5-Methylnorleucine; D-2-Amino-5-methylcaproic acid; D-5-Methylleucine (less common)
EINECS	Contact for details

Quality Control

Our 5-Methyl-D-Norleucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.