Description

Gastrin Releasing Peptide (20-26), Ala(24)- CAS NO 138749-62-9 is a synthetic peptide fragment of the gastrin-releasing peptide (GRP), specifically the C-terminal heptapeptide sequence with an alanine substitution at position 24. This modified sequence is a critical research tool for studying the GRP receptor (GRPR) signaling pathway and its role in various physiological and pathological processes. It is primarily utilized by researchers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on neurobiology, oncology, and gastrointestinal research. The compound's defined structure allows for precise investigation into receptor binding, antagonist development, and cellular response mechanisms.

Application

• Biomedical Research: Fundamental studies on the structure-activity relationship (SAR) of gastrin-releasing peptide and its receptor interactions.
• Neuroscience: Investigation of GRP's role in the central nervous system, including studies on satiety, stress response, and circadian rhythms.
• Oncology Research: Exploration of GRPR expression and signaling in certain cancers (e.g., prostate, lung, breast) for potential therapeutic targeting.
• Pharmacology: Used as a reference standard or tool compound in the development and screening of GRPR agonists or antagonists.
• Cell Signaling Studies: Analysis of intracellular pathways activated by GRPR binding in various cell lines.
• Biochemical Assays: Serves as a ligand in receptor binding assays and competitive inhibition experiments.

Basic Information

Product Name	Gastrin Releasing Peptide (20-26), Ala(24)- CAS NO 138749-62-9
CAS No.	138749-62-9
Molecular Formula	C38H61N11O10
Molecular Weight	831.97 g/mol
Synonyms	GRP (20-26), Ala24; [Ala24]-GRP (20-26); Gastrin-Releasing Peptide Fragment (20-26), Ala(24)-; H-His-Trp-Ala-Val-Gly-His-Ala-NH2; Ala24-Gastrin Releasing Peptide (20-26); Neuromedin C (20-26), Ala24-; GRP20-26 (Ala24); Research Peptide 138749-62-9
EINECS	Contact for details

Quality Control

Our Gastrin Releasing Peptide (20-26), Ala(24)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to specific purity levels (e.g., >95%, >98%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Consistent with reference standard
Purity (HPLC)	≥95%
Amino Acid Composition	Within ±10% of theoretical values
Peptide Content	≥80% (by weight)
Water Content (KF)	≤5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO), or acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.