Description

Cyclo(Glycyl-Arginyl-Glycyl-Aspartyl-Seryl-Aspartyl-Alanyl) is a synthetic cyclic peptide with the CAS number 138749-61-8. This compound is valued for its role as a potent and selective integrin antagonist, specifically targeting the αvβ3 and αvβ5 receptors. It is a critical research tool and a key intermediate in the development of novel therapeutics for conditions involving angiogenesis and cell adhesion. Industries requiring this high-purity biochemical include pharmaceutical R&D, biotechnology, and advanced materials science.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-angiogenic and anti-cancer therapies.
• Biochemical Assay Development: Used as a specific ligand in cell adhesion and integrin signaling pathway studies to understand metastasis and tumor growth.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the efficacy of integrin-targeting drug candidates.
• Peptide Chemistry & Conjugation: Serves as a sophisticated building block for the synthesis of more complex peptide-drug conjugates or diagnostic agents.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology, oncology, and vascular biology.

Basic Information

Item	Detail
Product Name	Cyclo(Glycyl-Arginyl-Glycyl-Aspartyl-Seryl-Aspartyl-Alanyl)
CAS No.	138749-61-8
Molecular Formula	C26H42N12O12
Molecular Weight	690.69 g/mol
Synonyms	Cyclo(Gly-Arg-Gly-Asp-Ser-Asp-Ala); c(RGDfSDA); Cyclo(GRGDfSDA); RGD Cyclic Peptide (fSDA variant); Integrin Antagonist Peptide; Cyclo(Gly-Arg-Gly-Asp-Ser-Asp-Ala) acetate; CTTHWGFTLC Peptide (related sequence); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Cyclo(Glycyl-Arginyl-Glycyl-Aspartyl-Seryl-Aspartyl-Alanyl) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade and cGMP-for-API intermediate standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.