Description

(2S)-4-(Dimethylamino)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Oxobutanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of specific amino acid sequences. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and fine chemical manufacturers developing therapeutic peptides, peptide-based drugs, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected aspartic acid derivative for the sequential assembly of peptide chains on resin supports.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including hormones, enzyme inhibitors, and targeted drug candidates.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic or therapeutic purposes.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: A valuable reagent for biochemical and structural biology studies involving peptide design and protein engineering.
• Production of Custom Peptides: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	(2S)-4-(Dimethylamino)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Oxobutanoic Acid
CAS No.	138585-02-1
Molecular Formula	C21H22N2O5
Molecular Weight	382.41 g/mol
Synonyms	Fmoc-Asp(OtBu)-OH; Fmoc-L-Aspartic acid 4-tert-butyl ester; Fmoc-Asp(OtBu)-OH; N-α-Fmoc-L-aspartic acid 4-tert-butyl ester; Fmoc-Asp(OtBu)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(dimethylamino)-4-oxobutanoic acid; Fmoc-Aspartic acid(OtBu); Fmoc-Asp(OtBu)
EINECS	Contact for details

Quality Control

Our (2S)-4-(Dimethylamino)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Oxobutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.