Description

4-Amino-2-Methyl-10H-Thiene[2,3-B][1,5]Benzodiazepine Hydrochloride is a high-purity, specialized benzodiazepine derivative with the CAS registry number 138564-60-0. This compound serves as a critical pharmaceutical intermediate and research chemical for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced synthetic chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel benzodiazepine-based therapeutic agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.
• Preclinical Studies: Employed in pharmacological and toxicological research for new drug candidates.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry and drug discovery projects.
• Custom Synthesis: Starting material for the contract manufacturing of complex, proprietary molecules.

Basic Information

Product Name	4-Amino-2-Methyl-10H-Thiene[2,3-B][1,5]Benzodiazepine Hydrochloride
CAS No.	138564-60-0
Molecular Formula	C14H14N4S • HCl
Molecular Weight	306.81 g/mol (Free base: 270.35)
Synonyms	4-Amino-2-methylthieno[2,3-b][1,5]benzodiazepine hydrochloride; 2-Methyl-4-aminothieno[2,3-b][1,5]benzodiazepine HCl; Thienobenzodiazepine derivative; AMTBD HCl; 138564-60-0; 4-Amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Methyl-10H-Thiene[2,3-B][1,5]Benzodiazepine Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.